Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC25A21
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    synthesized peptide derived from internal of human SLC25A21.

  • Positive control
    • human liver carcinoma tissue, extracts from HepG2 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab74106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 33 kDa.
ELISA 1/40000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Belongs to the mitochondrial carrier family.
    Contains 3 Solcar repeats.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Mitochondrial 2-oxodicarboxylate carrier antibody
    • ODC antibody
    • ODC_HUMAN antibody
    • ODC1 antibody
    • oxodicarboxylate carrier antibody
    • Slc25a21 antibody
    • Solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 antibody
    • Solute carrier family 25 member 21 antibody
    see all

Images

  • All lanes : Anti-SLC25A21 antibody (ab74106) at 1/500 dilution

    Lane 1 : extracts from HepG2 cells
    Lane 2 : extracts from HepG2 cells with immunizing peptide at 5 µg

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 33 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 28 kDa,48 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using 1/50 ab74106 with (right) or without (left) immunizing peptide.

References

This product has been referenced in:
  • Zhong Q & Kowluru RA Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Invest Ophthalmol Vis Sci 52:8739-46 (2011). WB ; Rat . Read more (PubMed: 22003103) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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