Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC25A22
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 52-300 of the Human SLC25A22 protein (Q9H936).

  • Positive control
    • WB: A431 and mouse brain whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab155250 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 34 kDa.

Target

  • Function
    Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+).
  • Tissue specificity
    Highly expressed in most tissues.
  • Involvement in disease
    Defects in SLC25A22 are the cause of epileptic encephalopathy early infantile type 3 (EIEE3) [MIM:609304]; also known as early myoclonic encephalopathy (EME) or neonatal epilepsy with suppression-burst pattern. Severe neonatal epilepsies with suppression-burst pattern are early-onset epileptic syndromes characterized by a typical EEG pattern. The suppression-burst pattern of the EEG is characterized by higher-voltage bursts of slow waves mixed with multifocal spikes alternating with isoelectric suppression phases. EME is characterized by a very early onset, erratic and fragmentary myoclonus, massive myoclonus, partial motor seizures and late tonic spasms. The prognosis of EME is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a persistent vegetative state. EME inheritance is autosomal recessive.
  • Sequence similarities
    Belongs to the mitochondrial carrier family.
    Contains 3 Solcar repeats.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GC 1 antibody
    • GC-1 antibody
    • GC1 antibody
    • GHC1_HUMAN antibody
    • Glutamate/H(+) symporter 1 antibody
    • Mitochondrial glutamate carrier 1 antibody
    • SLC25A22 antibody
    • Solute carrier family 25 member 22 antibody
    see all

Images

  • Anti-SLC25A22 antibody (ab155250) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 34 kDa



    10% SDS PAGE
  • Anti-SLC25A22 antibody (ab155250) at 1/1000 dilution + mouse brain whole cell lysate at 50 µg

    Predicted band size: 34 kDa



    10% SDS PAGE

References

ab155250 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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