The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesIHC-P: Use at a concentration of 1 - 2 µg/ml.
WB: Use at a concentration of 1 - 5 µg/ml.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
FunctionChloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.
Involvement in diseaseDefects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
Sequence similaritiesBelongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain.
Developmental stageExpression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.