The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
ELISA titre using peptide based assay: 1/312500.
Use a concentration of 1 µg/ml. Predicted molecular weight: 85 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
FunctionChloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.
Involvement in diseaseDefects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
Sequence similaritiesBelongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain.
Developmental stageExpression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.