Overview

  • Product nameAnti-SLC26A5 antibody
  • Description
    Mouse monoclonal to SLC26A5
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: DFTQVNFIDS VGVKTLAGIV KEYGDVGIYV YLAGCSAQVV NDLTRNRFFE NPALWELLFH SIHDAVLGSQ LREALAEQEA SAPPSQEDLE PNATPAT, corresponding to amino acids 645-742 of Human SLC26A5

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMotor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.
    • Involvement in diseaseDeafness, autosomal recessive, 61
    • Sequence similaritiesBelongs to the SLC26A/SulP transporter (TC 2.A.53) family.
      Contains 1 STAS domain.
    • Cellular localizationCell membrane. Lateral wall of outer hair cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • Deafness neurosensory autosomal recessive 61 antibody
      • DFNB 61 antibody
      • DFNB61 antibody
      • MGC118886 antibody
      • MGC118887 antibody
      • MGC118888 antibody
      • MGC118889 antibody
      • PRES antibody
      • Prestin (motor protein) antibody
      • Prestin antibody
      • S26A5_HUMAN antibody
      • SLC26A5 antibody
      • Solute carrier family 26 member 5 (prestin) antibody
      • Solute carrier family 26 member 5 antibody
      see all

    Anti-SLC26A5 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57776 SLC26A5 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-SLC26A5 antibody (ab57776)

    ab57776 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57776.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"