FunctionAcyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
Tissue specificityPredominantly expressed in liver.
Sequence similaritiesBelongs to the ATP-dependent AMP-binding enzyme family.
All lanes : Anti-SLC27A5 antibody (ab89008) at 1/500 dilution
Lane 1 : SLC27A5 transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size : 75 kDa Observed band size : 75 kDa
References for Anti-SLC27A5 antibody (ab89008)
This product has been referenced in:
Storey SM et al. Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol303:G837-50 (2012).
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