Overview

  • Product name
  • Description
    Rabbit polyclonal to SLC33A1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 215-264 (CNSVGQTAGY FLGNVLFLAL ESADFCNKYL RFQPQPRGIV TLSDFLFFWG) of human SLC33A1 (NP_004724).

  • Positive control
    • Human Placenta lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab83868 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides.
  • Tissue specificity
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
  • Involvement in disease
    Spastic paraplegia autosomal dominant 42 (SPG42) [MIM:612539]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Congenital cataracts, hearing loss, and neurodegeneration (CCHLND) [MIM:614482]: An autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the SLC33A transporter family.
  • Cellular localization
    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ACATN antibody
    • ACATN_HUMAN antibody
    • Acetyl CoA transporter antibody
    • Acetyl Coenzyme A transporter antibody
    • Acetyl coenzyme A transporter 1 antibody
    • Acetyl-CoA transporter 1 antibody
    • Acetyl-coenzyme A transporter 1 antibody
    • AT 1 antibody
    • AT-1 antibody
    • AT1 antibody
    • Human Angiotensin II Type 1 Receptor antibody
    • Slc33a1 antibody
    • Solute carrier family 33 (acetyl CoA transporter) member 1 antibody
    • Solute carrier family 33 member 1 antibody
    • spastic paraplegia 42 (autosomal dominant) antibody
    • SPG42 antibody
    see all

Anti-SLC33A1 antibody images

  • Anti-SLC33A1 antibody (ab83868) at 1 µg/ml (5% skim milk / PBS buffer) + Placenta lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 61 kDa
    Observed band size : 61 kDa

References for Anti-SLC33A1 antibody (ab83868)

This product has been referenced in:
  • Liu P  et al. S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model. Dis Model Mech 10:53-62 (2017). WB . Read more (PubMed: 27935820) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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