Overview

  • Product nameAnti-SLC37A4 antibody
    See all SLC37A4 primary antibodies
  • Description
    Rabbit polyclonal to SLC37A4
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 180 - 229 (SFLCLLLIHN EPADVGLRNL DPMPSEGKKG SLKEESTLQE LLLSPYLWVL) of Human SLC37A4 (NP_001458)

  • Positive control
    • OVCAR-3 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTransports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
  • Tissue specificityMostly expressed in liver and kidney.
  • Involvement in diseaseDefects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B) [MIM:232220]. GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease.
    Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C) [MIM:232240].
    Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D) [MIM:232240].
  • Sequence similaritiesBelongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • G6PT1 antibody
    • G6PT1_HUMAN antibody
    • G6PT2 antibody
    • G6PT3 antibody
    • Glucose-5-phosphate transporter antibody
    • Glucose-6-phosphatase, transport (glucose) protein 3 antibody
    • Glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1 antibody
    • Glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2; antibody
    • Glucose-6-phosphate translocase antibody
    • Glucose-6-phosphate transporter 1 antibody
    • GSD1b antibody
    • GSD1c antibody
    • GSD1d antibody
    • MGC15729 antibody
    • Microsomal glucose-6-phosphate transporter antibody
    • PRO0685 antibody
    • SLC37A4 antibody
    • Solute carrier family 37 (glucose-6-phosphate transporter), member 4 antibody
    • Solute carrier family 37 member 4 antibody
    • Transformation-related gene 19 protein antibody
    • TRG-19 antibody
    • TRG19 antibody
    see all

Anti-SLC37A4 antibody images

  • Anti-SLC37A4 antibody (ab90075) at 1 µg/ml (in 5% skim milk / PBS buffer) + OVCAR-3 cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 46 kDa

References for Anti-SLC37A4 antibody (ab90075)

ab90075 has not yet been referenced specifically in any publications.

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