The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/1000. Detects a band of approximately 74 kDa (predicted molecular weight: 57 kDa).
FunctionMay play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status.
Tissue specificityExpressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.
Involvement in diseaseMyopia 24, autosomal dominant
Sequence similaritiesBelongs to the ZIP transporter (TC 2.A.5) family.