Overview

  • Product name
  • Description
    Goat polyclonal to SLC47A1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-PEHPQDGAKLSRKQ

    , corresponding to internal sequence (near C-Terminus) amino acids 528-541 of Human SLC47A1 (NP_060712.2).

  • Positive control
    • Human Kidney lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab92295 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 62 kDa.
    Note: An additional band of unknown identity was also consistently observed at 26kDa. This band was successfully blocked by incubation with the immunizing peptide.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes.
    • Tissue specificity
      Expressed in adrenal gland, and to a lower extent in liver, skeletal muscle and kidney (especially found in luminal membranes of the urinary tubules, bile caniculi and brush border membranes).
    • Sequence similarities
      Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
    • Cellular localization
      Cell membrane. Predominantly localized at the plasma membrane but also found in intracellular organelles.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ10847 antibody
      • hMATE-1 antibody
      • hMATE1 antibody
      • MATE-1 antibody
      • MATE1 antibody
      • MGC6482 antibody
      • multidrug and toxin extrusion 1 antibody
      • Multidrug and toxin extrusion protein 1 antibody
      • S47A1_HUMAN antibody
      • SLC47A1 antibody
      • Solute carrier family 47 member 1 antibody
      see all

    Images

    • Anti-SLC47A1 antibody (ab92295) at 0.1 µg/ml + Human Kidney lysate in RIPA buffer at 35 µg

      Predicted band size : 62 kDa

    References

    ab92295 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab92295.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up