Overview

  • Product name
    Anti-SLC4A11 antibody
  • Description
    Goat polyclonal to SLC4A11
  • Host species
    Goat
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Horse, Chicken, Cow, Chimpanzee
  • Immunogen

    Synthetic peptide corresponding to Human SLC4A11 aa 109-123 (internal sequence) (Cysteine residue).
    Sequence:

    HTSRKYLKLKNFKEE


    Database link: NP_114423.1

  • Positive control
    • WB: Human kidney tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab99459 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 100 kDa).

Target

  • Function
    Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.
  • Tissue specificity
    Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
  • Involvement in disease
    Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD) [MIM:217400]; also known as corneal dystrophy and sensorineural deafness or Harboyan syndrome. CDPD consists of congenital corneal endothelial dystrophy and progressive perceptive deafness. Inheritance is autosomal recessive.
    Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2) [MIM:217700]; also known as congenital hereditary endothelial dystrophy of cornea. This bilateral corneal dystrophy is characterized by corneal opacification and nystagmus. Inheritance is autosomal recessive.
    Defects in SLC4A11 are the cause of corneal dystrophy Fuchs endothelial type 4 (FECD4) [MIM:613268]; also known as Corneal dystrophy Fuchs endothelial late-onset. It is an ocular disorder caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.
  • Sequence similarities
    Belongs to the anion exchanger (TC 2.A.31) family.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Cell membrane. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bicarbonate transporter related protein 1 antibody
    • Bicarbonate transporter-related protein 1 antibody
    • BTR1 antibody
    • CDPD antibody
    • CHED2 antibody
    • Corneal endothelial dystrophy 2 autosomal recessive antibody
    • dJ794I6.2 antibody
    • FECD4 antibody
    • MGC126418 antibody
    • MGC126419 antibody
    • NaBC1 antibody
    • S4A11_HUMAN antibody
    • Slc4a11 antibody
    • Sodium bicarbonate transporter-like protein 11 antibody
    • Sodium borate cotransporter 1 antibody
    • Sodium coupled borate cotransporter 1 antibody
    • Solute carrier family 4 member 11 antibody
    • Solute carrier family 4 sodium bicarbonate transporter like member 11 antibody
    • Solute carrier family 4 sodium borate transporter member 11 antibody
    see all

Images

  • Anti-SLC4A11 antibody (ab99459) at 0.3 µg/ml + Human kidney lysate in RIPA buffer at 35 µg

    Developed using the ECL technique.

    Predicted band size: 100 kDa
    Observed band size: 90 kDa (why is the actual band size different from the predicted?)
    Additional bands at: 26 kDa. We are unsure as to the identity of these extra bands.



    Primary incubation was 1 hour.

References

ab99459 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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