Overview

  • Product nameAnti-SLC4A5 antibody
  • Description
    Rabbit polyclonal to SLC4A5
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 899-948 (SIAHIDSLKM ETETSAPGEQ PQFLGVREQR VTGIIVFILT GISVFLAPIL) of Human SLC4A5 (NP_067019).

  • Positive control
    • THP-1 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab99131 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 126 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
  • Tissue specificityHighest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach and small intestine. Weakest expression seen in peripheral blood lymphocytes, colon, duodenum, jejunum, ileum and skeletal muscle.
  • Sequence similaritiesBelongs to the anion exchanger (TC 2.A.31) family.
  • Cellular localizationApical cell membrane. Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla.
  • Information by UniProt
  • Database links
  • Alternative names
    • Electrogenic sodium bicarbonate cotransporter 4 antibody
    • MGC129662 antibody
    • NBC4 antibody
    • NBCe2 antibody
    • S4A5_HUMAN antibody
    • SLC4A5 antibody
    • Solute carrier family 4 member 5 antibody
    • Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
    see all

Anti-SLC4A5 antibody images

  • Anti-SLC4A5 antibody (ab99131) at 1 µg/ml + THP-1 cell lysate at 10 µg

    Predicted band size : 126 kDa

References for Anti-SLC4A5 antibody (ab99131)

ab99131 has not yet been referenced specifically in any publications.

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