Overview

  • Product nameAnti-SLC4A8 antibody
    See all SLC4A8 primary antibodies
  • Description
    Mouse monoclonal to SLC4A8
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: IEEISDLILD QQELSSDLND SMRVKVREAL LKKHHHQNEK KRNNLIPIVR SFAEVGKKQS DPHLMDKHGQ TVSPQSVPTT NLEVKNGVNC EHSPVDLSKV , corresponding to amino acids 187-287 of Human SLC4A8

Properties

Applications

Our Abpromise guarantee covers the use of ab56708 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.
    • Tissue specificityExpressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.
    • Sequence similaritiesBelongs to the anion exchanger (TC 2.A.31) family.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Electroneutral Na(+)-driven Cl-HCO3 exchanger antibody
      • Electroneutral sodium bicarbonate exchanger 1 antibody
      • k-NBC3 antibody
      • S4A8_HUMAN antibody
      • Slc4a8 antibody
      • SLC4A8 protein antibody
      • Solute carrier family 4 member 8 antibody
      see all

    Anti-SLC4A8 antibody images

    • SLC4A8 antibody (ab56708) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human salivary gland.
    • Western blot against tagged recombinant protein immunogen using ab56708 SLC4A8 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-SLC4A8 antibody (ab56708)

    ab56708 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab56708.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"