Overview

  • Product name
    SLC7A5 peptide

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Amino acids
      1 to 100

Associated products

Specifications

Our Abpromise guarantee covers the use of ab192836 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SLC7A5 antibody (ab85226)

  • Purity
    70 - 90% by HPLC.

  • Form
    Lyophilised
  • Additional notes

    This is the blocking peptide for ab85226

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C.

General Info

  • Alternative names
    • 4F2 LC
    • 4F2 light chain
    • 4F2LC
    • CD98
    • CD98 light chain
    • CD98LC
    • D16S469E
    • DC49
    • E16
    • hLAT1
    • Integral membrane protein E16
    • L type amino acid transporter
    • L type amino acid transporter 1
    • L-type amino acid transporter 1
    • Large neutral amino acids transporter
    • Large neutral amino acids transporter 1
    • Large neutral amino acids transporter small subunit 1
    • LAT1
    • LAT1_HUMAN
    • Membrane protein E16
    • MPE16
    • Slc7a5
    • Sodium independent neutral amino acid transporter
    • Sodium independent neutral amino acid transporter LAT1
    • Solute carrier family 7 (cationic amino acid transporter y+ system) member 5
    • Solute carrier family 7 member 5
    • TA1
    • Tumor associated protein 1
    • y+ system cationic amino acid transporter
    see all
  • Function
    Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.
  • Tissue specificity
    Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2.
  • Sequence similarities
    Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
  • Cellular localization
    Cytoplasm > cytosol. Apical cell membrane. Located to the plasma membrane by SLC3A2/4F2hc. Localized to the apical membrane of placental syncytiophoblastic cells. Expressed in both luminal and abluminal membranes of brain capillary endothelial cells.
  • Information by UniProt

References

ab192836 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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