Overview

  • Product nameAnti-SLC7A7 antibody
    See all SLC7A7 primary antibodies
  • Description
    Mouse polyclonal to SLC7A7
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length human SLC7A7 protein (AAH03062.1)

  • Positive control
    • SLC7A7 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab69872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 47 kDa (predicted molecular weight: 56 kDa).

Target

  • FunctionInvolved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
  • Tissue specificityHighest expression in kidney and peripheral blood leukocytes. Weaker expression is observed in lung, heart, placenta, spleen, testis and small intestine. Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, retinal pigment epithelial cells, and various carcinoma cell lines, with highest expression in a colon-carcinoma cell line.
  • Involvement in diseaseLysinuric protein intolerance
  • Sequence similaritiesBelongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
  • Cellular localizationBasolateral cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • LAT3 antibody
    • LPI antibody
    • Monocyte amino acid permease 2 antibody
    • MOP-2 antibody
    • MOP2 antibody
    • SLC7A 7 antibody
    • Slc7a7 antibody
    • Solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 antibody
    • Solute carrier family 7 member 7 antibody
    • y(+)L type amino acid transporter 1 antibody
    • y(+)L-type amino acid transporter 1 antibody
    • Y+L amino acid transporter 1 antibody
    • y+LAT-1 antibody
    • Y+LAT1 antibody
    • YLAT1_HUMAN antibody
    see all

Anti-SLC7A7 antibody images

  • All lanes : Anti-SLC7A7 antibody (ab69872) at 1/500 dilution

    Lane 1 : SLC7A7 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 56 kDa
    Observed band size : 47 kDa (why is the actual band size different from the predicted?)

References for Anti-SLC7A7 antibody (ab69872)

ab69872 has not yet been referenced specifically in any publications.

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