Overview

  • Product nameAnti-SLC9A6 antibody
    See all SLC9A6 primary antibodies
  • Description
    Mouse monoclonal to SLC9A6
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment: YGDSTVNTEP ATSSAPRRFM GNSSEDALDR ELAFGDHELV IRGTRLVLPM DDSEPPLNLL DNTRHGPA, corresponding to amino acids 602-669 of human SLC9A6 (NP_006350) with a 26 kDa tag

  • Positive control
    • SLC9A6 transfected 293T cell lysate; recombinant tagged fragment of human SLC9A6 (the immunogen).

Properties

Applications

Our Abpromise guarantee covers the use of ab77110 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 74 kDa.
ELISA Use at an assay dependent dilution.

Target

  • FunctionElectroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
  • Tissue specificityUbiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.
  • Involvement in diseaseDefects in SLC9A6 are the cause of mental retardation syndromic X-linked Christianson type (MRXSC) [MIM:300243]; also known as MRXS-Christianson or X-linked Angelman-like syndrome. The phenotype is characterized by profound mental retardation, epilepsy, ataxia, and microcephaly, and showed phenotypic overlap with Angelman syndrome.
  • Sequence similaritiesBelongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
  • Cellular localizationEndosome membrane. Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3732426M05 antibody
    • 6430520C02Rik antibody
    • KIAA0267 antibody
    • mKIAA0267 antibody
    • MRSA antibody
    • Na(+)/H(+) exchanger 6 antibody
    • NHE-6 antibody
    • NHE6 antibody
    • OTTHUMP00000024089 antibody
    • OTTHUMP00000024090 antibody
    • RGD1563582 antibody
    • RP11-274K13.1 antibody
    • RP23-105E2.4 antibody
    • SL9A6_HUMAN antibody
    • SLC9A6 antibody
    • Sodium/hydrogen exchanger 6 antibody
    • Solute carrier family 9 (sodium/hydrogen exchanger), isoform 6 antibody
    • Solute carrier family 9 (sodium/hydrogen exchanger), member 6 antibody
    • Solute carrier family 9 member 6 antibody
    • solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 antibody
    see all

Anti-SLC9A6 antibody images

  • Anti-SLC9A6 antibody (ab77110) at 1/500 dilution + Recombinant fragment of human SLC9A6 at 0.2 µg

    Secondary
    Goat anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

    Predicted band size : 74 kDa
    Observed band size : 34 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-SLC9A6 antibody (ab77110) at 1/500 dilution

    Lane 1 : SLC9A6 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 74 kDa
    Observed band size : 65 kDa (why is the actual band size different from the predicted?)

References for Anti-SLC9A6 antibody (ab77110)

ab77110 has not yet been referenced specifically in any publications.

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