FunctionOrganic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg.
Tissue specificityPredominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.
Sequence similaritiesBelongs to the organo anion transporter (TC 2.A.60) family. Contains 1 Kazal-like domain.
Cellular localizationBasolateral cell membrane. Detected at the basolateral membrane of the proximal tubule cell in the kidney.