Overview

  • Product nameAnti-Slitrk1 antibody
    See all Slitrk1 primary antibodies
  • Description
    Rabbit polyclonal to Slitrk1
  • SpecificityThis antibody is predicted to have no cross-reactivity to other SLITRK proteins.
  • Tested applicationsSuitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (Human) of 18 amino acids from the central region.

  • Positive control
    • Human Brain Tissue Lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab67303 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 78 kDa).
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • RelevanceSlitrk1 is a member of a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette’s Syndrome, it is thought to play only a minor role if at all.
  • Cellular localizationMembrane; Single-pass type I membrane protein
  • Database links
  • Alternative names
    • SLITRK1 antibody
    • FLJ54428 antibody
    • KIAA0918 antibody
    • KIAA1910 antibody
    • Leucine rich repeat containing protein 12 antibody
    • LRRC1 antibody
    • LRRC12 antibody
    • RP11-395N17.1 antibody
    • SLIT and NTRK like family, member 1 antibody
    • SLIT and NTRK-like protein 1 antibody
    • slit and trk like gene 1 antibody
    • SLITRK 1 antibody
    • TTM antibody
    • UNQ233/PRO266 antibody
    see all

Anti-Slitrk1 antibody images

  • Immunofluorescence of Slitrk1 in Human brain tissue with ab67303at 20 ug/mL.

  • Immunohistochemistry of Human brain tissue with ab67303 used at 2.5 μg/ml

  • Lane 1 : Anti-Slitrk1 antibody (ab67303) at 1 µg/ml
    Lane 2 : Anti-Slitrk1 antibody (ab67303) at 2 µg/ml

    Lane 1 : Human brain tissue lysate
    Lane 2 : Human brain tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 78 kDa
    Observed band size : 90 kDa (why is the actual band size different from the predicted?)

References for Anti-Slitrk1 antibody (ab67303)

ab67303 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"