The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 160 kDa (predicted molecular weight: 107 kDa).
Use a concentration of 20 µg/ml.
RelevanceSLIT and NTRK-like family 5 (SLITRK5) is a member a protein family consisting of six homologous transmembrane proteins (SLITRK1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of SLITRK proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other SLITRK protein except SLITRK1, overexpression of SLITRK5 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.
Cellular localizationMembrane; Single-pass type I membrane protein.
Immunofluorescence of SLITRK5 in Human Brain cells using ab67309 at 5 µg/ml.
References for Anti-SLITRK5 antibody (ab67309)
This product has been referenced in:
Kogan-Sakin I et al. Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ : (2010).
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