Overview

  • Product nameAnti-SLU7 antibody
    See all SLU7 primary antibodies
  • Description
    Mouse monoclonal to SLU7
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-587 of Human SLU7

Properties

Applications

Our Abpromise guarantee covers the use of ab56710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionParticipates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
    • Sequence similaritiesBelongs to the SLU7 family.
      Contains 1 CCHC-type zinc finger.
    • DomainThe CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.
    • Cellular localizationNucleus. Cytoplasm. Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing.
    • Information by UniProt
    • Database links
    • Alternative names
      • 9G8 antibody
      • hSlu7 antibody
      • MGC9280 antibody
      • Pre mRNA splicing factor SLU7 antibody
      • Pre-mRNA-splicing factor slu7 antibody
      • SLU 7 antibody
      • slu7 antibody
      • SLU7 splicing factor homolog (S. cerevisiae) antibody
      • SLU7 splicing factor homolog antibody
      • SLU7_HUMAN antibody
      • splicing factor antibody
      • Step II splicing factor SLU7 antibody
      • Zinc knuckle motif containing antibody
      see all

    Anti-SLU7 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56710 SLU7 antibody at 1ug/ml. Predicted band size of immunogen is 91 kDa

    References for Anti-SLU7 antibody (ab56710)

    This product has been referenced in:
    • Dimmock NJ  et al. Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established. PLoS One 7:e49394 (2012). Functional Studies ; Ferret . Read more (PubMed: 23251341) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"