FunctionPromotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
Tissue specificityUbiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
DomainThe mature N-terminus mediates interaction with XIAP.
Cellular localizationMitochondrion. Released into the cytosol when cells undergo apoptosis.
Second mitochondria derived activator of caspase antibody
Second mitochondria-derived activator of caspase antibody
SMAC 3 antibody
Smac protein antibody
Anti-Smac / Diablo antibody images
Western blot - Smac antibody (ab8115)
All lanes : Anti-Smac / Diablo antibody (ab8115) at 1 µg/ml
Lane 1 : Mouse heart tissue lysate with absence of blocking peptide Lane 2 : Mouse heart tissue lysate with presence of blocking peptide Lane 3 : Rat heart tissue lysate with absence of blocking peptide
Immunofluorescence of Smac in Mouse Spleen cells using ab8115 at 10 ug/ml.
References for Anti-Smac / Diablo antibody (ab8115)
This product has been referenced in:
Shephard F et al. A mitochondrial location for haemoglobins--dynamic distribution in ageing and Parkinson's disease. Mitochondrion14:64-72 (2014).
Read more (PubMed: 24333691) »
Heazell AE et al. Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia. Reprod Sci15:1034-43 (2008).
Read more (PubMed: 19088373) »