Anti-Smac / Diablo antibody [AT19F2] (ab177526)

Overview

  • Product name
    Anti-Smac / Diablo antibody [AT19F2]
    See all Smac / Diablo primary antibodies
  • Description
    Mouse monoclonal [AT19F2] to Smac / Diablo
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Orangutan
  • Immunogen

    Recombinant full length protein corresponding to Human Smac aa 56-239. Sequence represents that of mature protein. Purified from E.coli. (NP_063940)
    Sequence:

    AVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED


    Database link: Q9NR28

  • Positive control
    • Jurkat cell line lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab177526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/3000.
WB 1/3000. Predicted molecular weight: 27 kDa.

Target

  • Function
    Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
  • Tissue specificity
    Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
  • Domain
    The mature N-terminus mediates interaction with XIAP.
  • Cellular localization
    Mitochondrion. Released into the cytosol when cells undergo apoptosis.
  • Information by UniProt
  • Database links
  • Alternative names
    • 0610041G12Rik antibody
    • DBLOH_HUMAN antibody
    • DBOH antibody
    • DFNA64 antibody
    • diablo antibody
    • Diablo homolog (Drosophila) antibody
    • Diablo homolog antibody
    • Diablo homolog mitochondrial antibody
    • Diablo IAP binding mitochondrial protein antibody
    • Diablo like protein antibody
    • DIABLO S antibody
    • Direct IAP binding protein with low pI antibody
    • Direct IAP-binding protein with low pI antibody
    • FLJ10537 antibody
    • FLJ25049 antibody
    • mitochondrial antibody
    • Mitochondrial Smac protein antibody
    • Second mitochondria derived activator of caspase antibody
    • Second mitochondria-derived activator of caspase antibody
    • SMAC 3 antibody
    • Smac antibody
    • Smac protein antibody
    • SMAC3 antibody
    see all

Images

  • Anti-Smac / Diablo antibody [AT19F2] (ab177526) at 1/3000 dilution + Jurkat cell line lysate at 40 µg

    Secondary
    Goat anti-mouse HRP conjugated antibody
    Developed using the ECL technique

    Predicted band size : 27 kDa

References

ab177526 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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