Overview

  • Product name
  • Description
    Rabbit polyclonal to SMARCD1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Cow, Human
  • Immunogen

    Synthetic peptide within Mouse SMARCD1 aa 309-335 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q61466

  • Positive control
    • Mouse heart tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab174337 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 58 kDa.

Target

  • Function
    Involved in chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
  • Tissue specificity
    Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta.
  • Sequence similarities
    Belongs to the SMARCD family.
    Contains 1 SWIB domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 60 kDa BRG-1/Brm-associated factor subunit A antibody
    • 60 kDa BRG1/Brm associated factor subunit A antibody
    • BAF60A antibody
    • BRG1 associated factor 60A antibody
    • BRG1-associated factor 60A antibody
    • Chromatin remodeling complex BAF60A subunit antibody
    • CRACD1 antibody
    • Mammalian chromatin remodeling complex BRG1 associated factor 60A antibody
    • Rsc6p antibody
    • SMARCD1 antibody
    • SMRD1 antibody
    • SMRD1_HUMAN antibody
    • SWI/SNF complex 60 kDa subunit A antibody
    • SWI/SNF complex 60 kDa subunit antibody
    • SWI/SNF related matrix associated actin dependent regulator of chromatin d1 antibody
    • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 antibody
    • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 antibody
    • Swp73 like protein antibody
    see all

Images

  • Anti-SMARCD1 antibody (ab174337) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 58 kDa

References

ab174337 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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