Overview

  • Product name
  • Description
    Mouse monoclonal to SMC6L1
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 1-110 of Human SMC6L1

  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

Properties

Applications

Our Abpromise guarantee covers the use of ab57759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notes
    WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies.
    • Tissue specificity
      Widely expressed. Overexpressed in testis.
    • Sequence similarities
      Belongs to the SMC family. SMC6 subfamily.
    • Domain
      The flexible hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC5, forming a V-shaped heterodimer.
    • Post-translational
      modifications
      Sumoylated by NSMCE2/MMS21.
      Ubiquitinated.
    • Cellular localization
      Nucleus. Chromosome. Chromosome > telomere. Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ22116 antibody
      • FLJ35534 antibody
      • hSMC6 antibody
      • SMC 6 antibody
      • SMC protein 6 antibody
      • SMC-6 antibody
      • SMC6 antibody
      • SMC6 protein antibody
      • SMC6 structural maintenance of chromosomes 6 like 1 antibody
      • SMC6_HUMAN antibody
      • Smc6l1 antibody
      • Structural maintenance of chromosomes 6 antibody
      • Structural maintenance of chromosomes 6 like 1 antibody
      • Structural maintenance of chromosomes protein 6 antibody
      see all

    Images

    • SMC6L1 antibody (ab57759) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.


    • Predicted band size : 126 kDa
      SMC6L1 antibody (ab57759) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References

    ab57759 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab57759.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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