Overview

  • Product name
  • Description
    Goat polyclonal to Smek1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Xenopus laevis, Zebrafish, a wide range of other species
  • Immunogen

    Synthetic peptide:

    C-EQQRERQDNPKLD

    , corresponding to internal sequence amino acids 645-657 of Human Smek1

  • Positive control
    • Human pancreas lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab63968 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    Peptide ELISA: antibody detection limit dilution : 1/16000.
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 100 kDa (predicted molecular weight: 95 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
    • Sequence similarities
      Belongs to the SMEK family.
      Contains 1 WH1 domain.
    • Cellular localization
      Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLFL1 antibody
      • KIAA2010 antibody
      • MEK1 SUPPRESSOR 1 antibody
      • MSTP033 antibody
      • P4R3A_HUMAN antibody
      • PP4R3 ALPHA antibody
      • PP4R3 antibody
      • PP4R3A antibody
      • PPP4R3A antibody
      • Protein phosphatase 4 regulatory subunit 3A antibody
      • PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 3, ALPHA antibody
      • Serine/threonine-protein phosphatase 4 regulatory subunit 3A antibody
      • SMEK homolog 1 antibody
      • SMEK homolog 1, suppressor of mek1 (Dictyostelium) antibody
      • smek1 antibody
      • Smk 1 antibody
      • SMK1 antibody
      see all

    Images

    References

    ab63968 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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