Anti-SMRC2 antibody (ab64853)

Overview

• Product name
  Anti-SMRC2 antibody
  See all SMRC2 primary antibodies
• Description
  Rabbit polyclonal to SMRC2
• Specificity
  ab64853 detects endogenous levels of total SMRC2 protein.
• Tested applications
  Suitable for: WB, ELISAmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse
• Immunogen

  Synthetic peptide derived from an internal region of human SMRC2.

• Positive control
  • Extracts from HUVEC cells and COLO205 cells.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• Storage buffer
  Preservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • Chromatin Remodeling
  • Swi / Snf

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Other factors

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

Applications

Target

• Function
  Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
• Tissue specificity
  Ubiquitously expressed.
• Sequence similarities
  Belongs to the SMARCC family.
  Contains 1 SANT domain.
  Contains 1 SWIRM domain.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession Q8TAQ2 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 6601 Human
  • Entrez Gene: 68094 Mouse
  • Omim: 601734 Human
  • SwissProt: Q8TAQ2 Human
  • SwissProt: Q6PDG5 Mouse
  • Unigene: 236030 Human
  • Unigene: 632717 Human
  • Unigene: 417338 Mouse
• Alternative names
  • BAF 170 antibody
  • BAF170 antibody
  • BRG1 associated factor 170 antibody

  • BRG1-associated factor 170 antibody
  • Chromatin remodeling complex BAF170 subunit antibody
  • CRACC 2 antibody
  • CRACC2 antibody
  • Mammalian chromatin remodeling complex BRG1 associated factor 170 antibody
  • Rsc 8 antibody
  • Rsc8 antibody
  • SMARCC 2 antibody
  • Smarcc2 antibody
  • SMRC2_HUMAN antibody
  • SWI/SNF complex 170 kDa subunit antibody
  • SWI/SNF complex subunit SMARCC2 antibody
  • SWI/SNF related matrix associated actin dependent regulator of chromatin c2 antibody
  • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 antibody
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 antibody
  • SWI3 like protein antibody

  see all

Protocols

• Western blot protocols