Overview

  • Product nameAnti-SMRC2 antibody
    See all SMRC2 primary antibodies
  • Description
    Rabbit polyclonal to SMRC2
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region between amino acid 1164 and the C terminus (amino acid 1214) of human SMRC2 (NP_003066.2).

  • Positive control
    • Human controls: Anaplastic Thyroid Carcinoma, Bladder Cell Carcinoma, Breast Carcinoma, Colon Carcinoma, Laryngeal Squamous Cell Carcinoma, Linitis Plastica Stomach Cancer, Lung Adenocarcinoma, Metastatic Lymph Node, Non Small Cell Lung Cancer, Ovarian Carcinoma, Prostate Carcinoma, Skin Basal Cell Carcinoma, Stomach Adenocarcinoma and Testicular Seminoma.
      Mouse Control: Squamous Cell Carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84453 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500.
    Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
    • Tissue specificityUbiquitously expressed.
    • Sequence similaritiesBelongs to the SMARCC family.
      Contains 1 SANT domain.
      Contains 1 SWIRM domain.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • BAF 170 antibody
      • BAF170 antibody
      • BRG1 associated factor 170 antibody
      • BRG1-associated factor 170 antibody
      • Chromatin remodeling complex BAF170 subunit antibody
      • CRACC 2 antibody
      • CRACC2 antibody
      • Mammalian chromatin remodeling complex BRG1 associated factor 170 antibody
      • Rsc 8 antibody
      • Rsc8 antibody
      • SMARCC 2 antibody
      • Smarcc2 antibody
      • SMRC2_HUMAN antibody
      • SWI/SNF complex 170 kDa subunit antibody
      • SWI/SNF complex subunit SMARCC2 antibody
      • SWI/SNF related matrix associated actin dependent regulator of chromatin c2 antibody
      • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 antibody
      • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 antibody
      • SWI3 like protein antibody
      see all

    Anti-SMRC2 antibody images

    • ab84453, at a 1/500 dilution, staining SMRC2 in formalin fixed, paraffin embedded human prostate adenocarcinoma by Immunohistochemistry.
      Detection: using DAB staining.
    • ab84453, at 1/500 dilution, staining SMRC2 in formalin fixed, paraffin embedded mouse squamous cell carcinoma by Immunohistochemistry.
      Detection: using DAB staining.

    References for Anti-SMRC2 antibody (ab84453)

    ab84453 has not yet been referenced specifically in any publications.

    Product Wall

    Gracias por contactarnos.

    He chequeado la homología de dichos anticuerpos con BAF155, y el resultado es el siguiente:

    ab64853: Al llevar a cabo un alineamiento de secuencias con BAFF15 (http://www.uniprot.org/uniprot/Q92922) ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"