The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SMURF1 antibody (ab40823)
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
E3 ubiquitin-protein ligase SMURF1
Smad specific E3 ubiquitin ligase 1
SMAD specific E3 ubiquitin protein ligase 1
Smad ubiquitination regulatory factor 1
SMAD-specific E3 ubiquitin-protein ligase 1
FunctionE3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.
PathwayProtein modification; protein ubiquitination.