Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      PSEGSLEDEELPAQ
    • Amino acids
      359 to 372

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45831 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SMURF1 antibody (ab40823)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • E3 ubiquitin-protein ligase SMURF1
    • hSMURF1
    • KIAA1625
    • Smad specific E3 ubiquitin ligase 1
    • SMAD specific E3 ubiquitin protein ligase 1
    • Smad ubiquitination regulatory factor 1
    • SMAD-specific E3 ubiquitin-protein ligase 1
    • SMUF1_HUMAN
    • SMURF 1
    • smurf1
    see all
  • Function
    E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Acts by mediating ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Contains 1 C2 domain.
    Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
    Contains 2 WW domains.
  • Post-translational
    modifications
    Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt

References for SMURF1 peptide (359-372) (ab45831)

ab45831 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45831.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up