Anti-SNAP25 Interacting Protein antibody (ab111343)

Overview

  • Product nameAnti-SNAP25 Interacting Protein antibody
  • Description
    Rabbit polyclonal to SNAP25 Interacting Protein
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from an internal region of Human SNAP25 Interacting Protein.

  • Positive control
    • HepG2 and HeLa cell extracts.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab111343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 112 kDa.

Target

  • FunctionActs as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
  • Tissue specificityExpressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
  • Sequence similaritiesBelongs to the SRCIN1 family.
  • Post-translational
    modifications
    Tyrosine-phosphorylated in response to EGF and to cell adhesion to integrin ligands.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. Cell projection > axon. Cell projection > dendrite. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.
  • Information by UniProt
  • Database links
  • Alternative names
    • p130Cas associated protein antibody
    • p130Cas-associated protein antibody
    • P140 antibody
    • p140Cap antibody
    • SNAP-25-interacting protein antibody
    • SNIP antibody
    • SRC kinase signaling inhibitor 1 antibody
    • SRCIN1 antibody
    • SRCN1_HUMAN antibody
    see all

Anti-SNAP25 Interacting Protein antibody images

  • All lanes : Anti-SNAP25 Interacting Protein antibody (ab111343) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HepG2 cell extract
    Lane 3 : HepG2 cell extract with immunizing peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 112 kDa

References for Anti-SNAP25 Interacting Protein antibody (ab111343)

ab111343 has not yet been referenced specifically in any publications.

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