This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 0.5mg/ml Tris-saline. pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesPurified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

  • Application notesPeptide ELISA: antibody detection limit dilution 1/16000.
    WB: preliminary experiments give no signal but low background in human brain and testis lysates at up to 1µg/ml (note whole-cell RIPA lysates not nuclear lysates).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.
    • Tissue specificityExpressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
    • Sequence similaritiesBelongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
    • Cellular localizationNucleus. In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.
    • Information by UniProt
    • Database links
    • Alternative names
      • Dclre1a antibody
      • DCR1A_HUMAN antibody
      • DNA cross link repair 1A antibody
      • DNA cross link repair gene SNM1 antibody
      • DNA cross-link repair 1A protein antibody
      • hSNM1 antibody
      • hSNM1A antibody
      • PSO2 antibody
      • SNM1 homolog A antibody
      see all

    References for Anti-SNM1A antibody (ab14805)

    ab14805 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab14805.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"