This fast track antibody is not yet fully characterized. It is subject to these terms and conditions

Overview

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 0.5mg/ml Tris-saline. pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

  • Application notes
    Peptide ELISA: antibody detection limit dilution 1/16000.
    WB: preliminary experiments give no signal but low background in human brain and testis lysates at up to 1µg/ml (note whole-cell RIPA lysates not nuclear lysates).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.
    • Tissue specificity
      Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
    • Sequence similarities
      Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
    • Cellular localization
      Nucleus. In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.
    • Information by UniProt
    • Database links
    • Alternative names
      • Dclre1a antibody
      • DCR1A_HUMAN antibody
      • DNA cross link repair 1A antibody
      • DNA cross link repair gene SNM1 antibody
      • DNA cross-link repair 1A protein antibody
      • hSNM1 antibody
      • hSNM1A antibody
      • PSO2 antibody
      • SNM1 homolog A antibody
      see all

    References

    This product has been referenced in:
    • Iyama T  et al. CSB interacts with SNM1A and promotes DNA interstrand crosslink processing. Nucleic Acids Res 43:247-58 (2015). WB . Read more (PubMed: 25505141) »
    • Sengerová B  et al. Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. J Biol Chem 287:26254-67 (2012). Read more (PubMed: 22692201) »

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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