Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab79012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/16000.
IHC-P Use a concentration of 2.5 µg/ml.

Target

  • Function
    May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.
  • Tissue specificity
    Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
  • Sequence similarities
    Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
  • Cellular localization
    Nucleus. In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dclre1a antibody
    • DCR1A_HUMAN antibody
    • DNA cross link repair 1A antibody
    • DNA cross link repair gene SNM1 antibody
    • DNA cross-link repair 1A protein antibody
    • hSNM1 antibody
    • hSNM1A antibody
    • PSO2 antibody
    • SNM1 homolog A antibody
    see all

Images

  • ab79012, at 2.5µg/ml, staining SNM1A in human heart tissue by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

References

ab79012 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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