Overview

  • Product name
  • Description
    Goat polyclonal to SNX15
  • Specificity
    This antibody is expected to recognise both human isoforms.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    EEILRLHLSQLPP

    , corresponding to C terminal amino acids 330-342 of Human SNX15.

  • Positive control
    • 293 or human kidney cell lysate.
  • General notes
    Principal Names – SNX15; HSAF001435; sorting nexin 15; clone iota unknown protein Official Gene Symbol - SNX15 GenBank Accession Number – SNX15 LocusLink ID - 29907 (human) Gene Ontology terms - protein transporter activity; intracellular protein transport; intracellular signaling cascade; membrane; cytosol

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • Purity
    IgG fraction
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab3990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.2 - 1 µg/ml.

Target

  • Function
    May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the sorting nexin family.
    Contains 1 MIT domain.
    Contains 1 PX (phox homology) domain.
  • Domain
    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Cellular localization
    Cytoplasm. Membrane. Cytoplasmic vesicle membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Clone iota unknown protein antibody
    • HSAF001435 antibody
    • SNX 15 antibody
    • SNX15 antibody
    • SNX15_HUMAN antibody
    • Sorting nexin 15 antibody
    • Sorting nexin-15 antibody
    see all

Images

  • ab3990 staining (0.5µg/ml) of 293 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

References

This product has been referenced in:
  • Danson C  et al. SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome. J Cell Sci 126:4885-99 (2013). WB . Read more (PubMed: 23986476) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab3990.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up