Overview

  • Product name
  • Description
    Goat polyclonal to SNX16
  • Specificity
    This antibody is expected to recognise all three human isoforms.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide: ATPYVPVPMPIGN, corresponding to N terminal amino acids 2-14 of Human SNX16.

  • General notes
    Principal Names - SNX16; DKFZp666H147; sorting nexin 16 Official Gene Symbol - SNX16 (interim symbol) GenBank Accession Number – NP_071416; NP_690049; NP_690050 LocusLink ID - 64089 (human); 74718 (mouse); 64088 (rat) Gene Ontology terms - protein transporter activity; intracellular protein transport; intracellular signaling cascade; kinesin complex.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
  • Concentration information loading...
  • Purity
    IgG fraction
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab4151 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.05 - 0.2 µg/ml. Detects a band of approximately 38 kDa (predicted molecular weight: 39 kDa).Can be blocked with Human SNX16 peptide (ab22994). In transfected HEK293 transiently expressing SNX16 a band of approx. 40kDa is observed. This band is not observed in the non-transfected HEK293.

Target

  • Function
    May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
  • Tissue specificity
    Detected in placenta, lung, liver,heart and pancreas.
  • Sequence similarities
    Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
  • Domain
    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
  • Cellular localization
    Early endosome membrane. Late endosome membrane. Cytoplasm. Lysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp666H147 antibody
    • OTTHUMP00000227313 antibody
    • OTTHUMP00000227314 antibody
    • SNX16 antibody
    • SNX16_HUMAN antibody
    • Sorting nexin-16 antibody
    see all

Images

References

ab4151 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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