• Product name
  • Description
    Rabbit polyclonal to SNX3
  • Tested applications
    Suitable for: WB, ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Human, Recombinant fragment
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide (Human) sequence C-terminal end.


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab56078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 19 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA Use at an assay dependent dilution.
ICC/IF Use a concentration of 1 - 5 µg/ml.


  • Function
    Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol-3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.
  • Involvement in disease
    A chromosomal aberration involving SNX3 may be a cause of microphthalmia syndromic type 8 (MCOPS8) [MIM:601349]. Translocation t(6;13)(q21;q12). Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS8 is a very rare congenital syndrome characterized by microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported.
  • Sequence similarities
    Belongs to the sorting nexin family.
    Contains 1 PX (phox homology) domain.
  • Domain
    The PX domain mediates specific binding to phosphatidylinositol-3-phosphate (PtdIns(P3)).
  • Post-translational
    Ubiquitinated, leading to its proteasomal degradation. Deubiquitinated by USP10.
  • Cellular localization
    Early endosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Grd19 antibody
    • MCOPS8 antibody
    • MGC151262 antibody
    • MGC151266 antibody
    • MGC17570 antibody
    • OTTHUMP00000016941 antibody
    • OTTHUMP00000046475 antibody
    • OTTHUMP00000046476 antibody
    • Protein SDP3 antibody
    • SDP3 antibody
    • SNX3 antibody
    • SNX3_HUMAN antibody
    • SNX3A antibody
    • Sorting nexin 3 antibody
    • Sorting nexin 3A antibody
    • Sorting nexin-3 antibody
    see all

Anti-SNX3 antibody images

  • ICC/IF image of ab56078 stained Hek293 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab56078, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

References for Anti-SNX3 antibody (ab56078)

This product has been referenced in:
  • Morel E  et al. Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun 4:2250 (2013). Read more (PubMed: 23907271) »

See 1 Publication for this product

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Western blot
Loading amount
40 µg
Gel Running Conditions
Reduced Denaturing (4-20% gradient gel)
Mouse Cell lysate - whole cell (MEF, mouse Raw264 cells)
MEF, mouse Raw264 cells
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 22°C

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Submitted Sep 15 2014


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