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Product name Anti-SOCS4 antibody See all SOCS4 primary antibodies
Goat polyclonal to SOCS4
Tested applications Suitable for:
WB, IHC-P more details
Predicted to work with:
SKVRVLRIDAPEQQ , corresponding to C terminal amino acids 426-439 of Human SOCS7.
General notes Principal Names – SOCS7; SOCS4; suppressor of cytokine signaling 7; SH2 domain containing SOCS box protein.
Official Gene Symbol - SOCS7.
GenBank Accession Number – NP_543143.
LocusLink ID - 122809 (human).
Gene Ontology terms - intracellular signaling cascade; regulation of cell growth.
Storage instructions Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer Preservative: 0.02% Sodium Azide
Constituents: 0.5% BSA, 5mg/ml Tris, pH 7.3
Concentration information loading...
Purity IgG fraction
Purification notes Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 3 µg/ml.
Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway Protein modification; protein ubiquitination.
Sequence similarities Contains 1 SH2 domain. Contains 1 SOCS box domain.
Domain The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Information by UniProt
Cytokine inducible SH2 protein 4 antibody
Anti-SOCS4 antibody images
Western blot - SOCS4 antibody (ab3607)
ab3607 at a 2µg/ml concentration staining ~50 kDa SOCS 7 in NIH-3T3 cell lysate (RIPA buffer, 30µg total protein per lane) by Western blot. 1 hour incubation, ECL detection.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS4 antibody (ab3607)
ab3607 (3.8µg/ml) staining of paraffin embedded Human Pancreas shows cytoplasm staining on select beta cells in islet of Langerhans. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
References for Anti-SOCS4 antibody (ab3607)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"