Overview

  • Product nameAnti-SOCS4 antibody
    See all SOCS4 primary antibodies
  • Description
    Mouse polyclonal to SOCS4
  • Tested applicationsSuitable for: WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-440 of Human SOCS4 (NP_543143.1)

  • Positive control
    • Hela cells, SOCS4 transfected 293T cell line and HeLa cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein A purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab88545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa.
ICC/IF Use a concentration of 10 µg/ml.

Target

  • FunctionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • DomainThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CIS4 antibody
    • Cish4 antibody
    • Cytokine inducible SH2 protein 4 antibody
    • DKFZp686J1568 antibody
    • HSPC060 antibody
    • SH2 domain containing SOCS box protein antibody
    • SOCS-4 antibody
    • SOCS-7 antibody
    • SOCS4 antibody
    • SOCS4_HUMAN antibody
    • SOCS6 antibody
    • SOCS7 antibody
    • SSI4 antibody
    • STAI4 antibody
    • STAT induced STAT inhibitor 4 antibody
    • STAT4 antibody
    • STATI4 antibody
    • Suppressor of cytokine signaling 4 antibody
    • Suppressor of cytokine signaling 7 antibody
    see all

Anti-SOCS4 antibody images

  • Immunofluorescence of ab88545 to SOCS4 on HeLa cells (antibody concentration 10 ug/ml)
  • Anti-SOCS4 antibody (ab88545) at 1 µg/ml + Hela cell lysate at 50 µg

    Predicted band size : 53 kDa
    Observed band size : 53 kDa
  • All lanes : Anti-SOCS4 antibody (ab88545) at 1 µg/ml

    Lane 1 : transfected 293T cell lysate
    Lane 2 : non transfected 293T cell lysate

    Lysates/proteins at 50 µg per lane.


    Predicted band size : 53 kDa
    Observed band size : 53 kDa

References for Anti-SOCS4 antibody (ab88545)

This product has been referenced in:
  • Naqvi AR  et al. MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages. Innate Immun N/A:N/A (2013). Read more (PubMed: 24062196) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"