General notesab94295 is a 293T cell transfected lysate in which Human SOCS4 has been transiently over-expressed using a pCMV-SOCS4 plasmid. The lysate is provided in 1 x Sample Buffer. Note: For more details about how the transfected lysate was prepared view preparation notes
BackgroundFunction: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Pathway: Protein modification; protein ubiquitination.
Similarity: Contains 1 SH2 domain.
Contains 1 SOCS box domain.
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.