The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notesWB: 1/500 - 1/1000. Predicted molecular weight: 60 kDa. This antibody has only been tested against over-expressing cell lines and against the recombinant fusion protein used as immunogen.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
PathwayProtein modification; protein ubiquitination.