This fast track antibody is not yet fully characterized. It is subject to these terms and conditions



  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesThis antibody is affinity purified.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


  • Application notesWB: 1/1000. This antibody was tested against the recombinant protein fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRegulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    • Tissue specificityExpressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesContains 1 SH2 domain.
      Contains 1 SOCS box domain.
    • DomainThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
    • Cellular localizationCytoplasm. Cell membrane. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ash and phospholipase C gamma-binding protein antibody
      • NAP 4 antibody
      • NAP 4 Fragment antibody
      • NAP-4 antibody
      • NAP4 antibody
      • Nck antibody
      • Nck Ash and phospholipase C binding protein antibody
      • Nck Ash and phospholipase C gamma binding protein antibody
      • Nck associated protein 4 antibody
      • Nck-associated protein 4 antibody
      • NCKAP4 antibody
      • SH2 domain containing SOCS box protein antibody
      • SOCS 7 antibody
      • SOCS-7 antibody
      • SOCS4 antibody
      • SOCS6 antibody
      • Socs7 antibody
      • SOCS7_HUMAN antibody
      • Suppressor of cytokine signaling 7 antibody
      see all

    References for Anti-SOCS7 antibody (ab13951)

    This product has been referenced in:
    • Pereira CP  et al. Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages. PLoS One 5:e15352 (2010). WB ; Human . Read more (PubMed: 20976180) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab13951.
    Please use the links above to contact us or submit feedback about this product.