• FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab80603 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab80603 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesPeptide ELISA: antibody detection limit dilution 1/32000
    WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionRegulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    • Tissue specificityExpressed in brain and leukocytes. Also in fetal lung fibroblasts and fetal brain.
    • PathwayProtein modification; protein ubiquitination.
    • Sequence similaritiesContains 1 SH2 domain.
      Contains 1 SOCS box domain.
    • DomainThe SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). It is required for IRS1 ubiquitination and subsequent proteasomal degradation.
    • Cellular localizationCytoplasm. Cell membrane. Nucleus. Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Rapidly relocalizes to the nucleus after UV irradiation. Cytoplasmic location depends upon SEPT7 presence.
    • Information by UniProt
    • Database links
    • Alternative names
      • Ash and phospholipase C gamma-binding protein antibody
      • NAP 4 antibody
      • NAP 4 Fragment antibody
      • NAP-4 antibody
      • NAP4 antibody
      • Nck antibody
      • Nck Ash and phospholipase C binding protein antibody
      • Nck Ash and phospholipase C gamma binding protein antibody
      • Nck associated protein 4 antibody
      • Nck-associated protein 4 antibody
      • NCKAP4 antibody
      • SH2 domain containing SOCS box protein antibody
      • SOCS 7 antibody
      • SOCS-7 antibody
      • SOCS4 antibody
      • SOCS6 antibody
      • Socs7 antibody
      • SOCS7_HUMAN antibody
      • Suppressor of cytokine signaling 7 antibody
      see all

    Anti-SOCS7 antibody images

    • Anti-SOCS7 antibody (ab80603) at 1 µg/ml + Daudi lysate (in RIPA buffer) at 35 µg

      Predicted band size : 63 kDa
      Observed band size : 63 kDa
      Additional bands at : 28 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-SOCS7 antibody (ab80603)

    ab80603 has not yet been referenced specifically in any publications.

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