Overview

  • Product name
    Anti-SOD2/MnSOD antibody [1AE]
    See all SOD2/MnSOD primary antibodies
  • Description
    Mouse monoclonal [1AE] to SOD2/MnSOD
  • Host species
    Mouse
  • Tested applications
    Suitable for: ELISA, IPmore details
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Recombinant full length protein (Human).

  • Positive control
    • HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab16952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IP
  • Application notes
    ELISA: Use at an assay dependent dilution.
    IP: Use at a concentration of 1 - 2 µg/ml lysate.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
    • Involvement in disease
      Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
    • Sequence similarities
      Belongs to the iron/manganese superoxide dismutase family.
    • Post-translational
      modifications
      Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
    • Cellular localization
      Mitochondrion matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • Indophenoloxidase B antibody
      • IPO B antibody
      • IPOB antibody
      • Manganese containing superoxide dismutase antibody
      • Manganese SOD antibody
      • Manganese superoxide dismutase antibody
      • Mangano superoxide dismutase antibody
      • Mn SOD antibody
      • Mn superoxide dismutase antibody
      • MNSOD antibody
      • MVCD6 antibody
      • SOD 2 antibody
      • SOD2 antibody
      • SODM_HUMAN antibody
      • Superoxide dismutase [Mn] mitochondrial antibody
      • Superoxide dismutase [Mn], mitochondrial antibody
      • Superoxide dismutase 2 mitochondrial antibody
      see all

    Images

    • Immunoprecipitation of Hela cell lysates staing SOD2 with abab16952. Lane 1 Input, Lane 2 Precipitates.

    References

    ab16952 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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