Overview

  • Product name
    Sodium picosulfate
  • Description
    Inhibits absorption of water and electrolytes, and increases their secretion
  • Alternative names
    • Sodium picosulphate
  • Biological description

    Prodrug metabolized by gut bacteria into the active compound bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) which is a contact stimulant laxative and increases peristalsis in the gut, preventing the absorption of water by the colon.

Properties

  • Chemical name
    [4-[Pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate disodium salt
  • Molecular weight
    481.41
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H13NNa2O8S2
  • CAS Number
    10040-45-6
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 5 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Tzavella K  et al. Effects of long-term treatment with anthranoids and sodium picosulphate on the contents of vasoactive intestinal polypeptide, somatostatin and substance P in the rat colon. Eur J Gastroenterol Hepatol 7:13-20 (1995). Read more (PubMed: 7532534) »
  • Fioramonti J  et al. In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology 47 Suppl 1:155-61 (1993). Read more (PubMed: 8234424) »
  • Nishikawa J & Kast A Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung 31:321-5 (1981). Read more (PubMed: 7194649) »
  • Jauch R  et al. Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate. Arzneimittelforschung 25:1796-1800 (1975). Read more (PubMed: 1243088) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145728.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up