Inhibits absorption of water and electrolytes, and increases their secretion
Prodrug metabolized by gut bacteria into the active compound bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM) which is a contact stimulant laxative and increases peristalsis in the gut, preventing the absorption of water by the colon.
[4-[Pyridin-2-yl-(4-sulfonatooxyphenyl)methyl]phenyl] sulfate disodium salt
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 5 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Tzavella K et al. Effects of long-term treatment with anthranoids and sodium picosulphate on the contents of vasoactive intestinal polypeptide, somatostatin and substance P in the rat colon. Eur J Gastroenterol Hepatol7:13-20 (1995).
Read more (PubMed: 7532534) »
Fioramonti J et al. In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology47 Suppl 1:155-61 (1993).
Read more (PubMed: 8234424) »
Nishikawa J & Kast A Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung31:321-5 (1981).
Read more (PubMed: 7194649) »
Jauch R et al. Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate. Arzneimittelforschung25:1796-1800 (1975).
Read more (PubMed: 1243088) »