FunctionMay act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1.
Tissue specificityBroad expression. High expression in thalamus and brain. Significantly expressed in vasculature.
Sequence similaritiesBelongs to the SOLO family. Contains 1 CRAL-TRIO domain. Contains 3 spectrin repeats.