Anti-soluble TNF Receptor I antibody (ab28749)

Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab28749 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/128000.
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 28 kDa.

Target

  • Relevance
    TNF RI (CD120a) is a 55 kDa transmembrane glycoprotein that is expressed by virtually all nucleated mammalian cells. Among the numerous cells known to express TNF RI are hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34+ hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF RI. Soluble TNF alpha binds with a Kda in the range of 20-60 pM, while TNF beta binds with a Kda equal to 650 pM. TNF RI relative to TNF RII seems to be the more physiologically relevant receptor, whereas TNF R2 appears to play a direct role in only a limited number of TNF responses. Soluble TNF RI, which blocks TNF alpha activity, has been identified in both urine and blood (1-3 ng/mL). Serum levels of sTNF receptors increase dramatically in certain pathological situations.
  • Cellular localization
    Cytoplasmic
  • Database links
  • Alternative names
    • CD120a antibody
    • TBP1 antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFRSF1A antibody
    • Tumor necrosis factor receptor 1 antibody
    see all

Images

References

ab28749 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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