Anti-soluble TNF Receptor I antibody (ab9979)

Overview

  • Product nameAnti-soluble TNF Receptor I antibodySee all Soluble TNF Receptor I primary antibodies ...
  • Description
    Rabbit polyclonal to soluble TNF Receptor I
  • Tested applicationsWB, ELISA, Neutralising more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Highly pure (>98%) recombinant hsTNF-R1 (human soluble Tumor Necrosis Factor Receptor-1)

Properties

Applications

Our Abpromise guarantee covers the use of ab9979 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB Use a concentration of 0.1 - 0.2 µg/ml.
ELISA Use a concentration of 0.5 µg/ml.
Neutralising Use at an assay dependent dilution. To yield one-half maximal inhibition [ND50] of the biological activity of hsTNF-R1 (0.3 µg/ml), a concentration of 0.9 - 1.1 µg/ml of this antibody is required.

Target

  • RelevanceTNF RI (CD120a) is a 55 kDa transmembrane glycoprotein that is expressed by virtually all nucleated mammalian cells. Among the numerous cells known to express TNF RI are hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34+ hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF RI. Soluble TNF alpha binds with a Kda in the range of 20-60 pM, while TNF beta binds with a Kda equal to 650 pM. TNF RI relative to TNF RII seems to be the more physiologically relevant receptor, whereas TNF R2 appears to play a direct role in only a limited number of TNF responses. Soluble TNF RI, which blocks TNF alpha activity, has been identified in both urine and blood (1-3 ng/mL). Serum levels of sTNF receptors increase dramatically in certain pathological situations.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • CD120a antibody
    • Soluble TNF p55 Receptor antibody
    • TBP1 antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFRSF1A antibody
    • Tumor necrosis factor alpha receptor antibody
    • Tumor necrosis factor receptor 1 antibody
    see all

References for Anti-soluble TNF Receptor I antibody (ab9979)

ab9979 has not yet been referenced specifically in any publications.

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