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Anti-Soluble TNF Receptor II antibody (Biotin) (ab17552)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab17552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: Use a concentration of 0.15 - 0.3 µg/ml.
WB WB: Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 48 kDa.

Target

  • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • Sequence similaritiesContains 4 TNFR-Cys repeats.
  • Post-translational
    modifications    Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
    A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P20333 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CD120b antibodyp75 antibodyp75 TNF receptor antibody
        p75TNFR antibodyp80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodySoluble TNFR1B variant 1 antibodyTBP-2 antibodyTBPII antibodyTNF R II antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFBR antibodyTNFR-II antibodyTNFR1B antibodyTNFR2 antibodyTNFR80 antibodyTnfrsf1b antibodyTNR1B_HUMAN antibodyTumor necrosis factor beta receptor antibodyTumor necrosis factor binding protein 2 antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor superfamily, member 1B antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody
      see all

    References for Anti-Soluble TNF Receptor II antibody (Biotin) (ab17552)

    ab17552 has not yet been referenced specifically in any publications.

    Publishing research using ab17552 ? Please let us know so that we can cite the reference in this datasheet

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    Hello, What is the source of the immunogen used to generate this antibody? That is, was the rabbit immunized with native protein, or recombinant expressed in E. coli or insect or COS cell? Thank you,

    Thank you for your enquiry and your interest in our products. The immunogen is a highly pure (>98%) recombinant hsTNF Receptor (human sTNF Receptor) expressed in E. coli.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"