Anti-Soluble TNF Receptor II antibody (Biotin) (ab17552)
- Product nameAnti-Soluble TNF Receptor II antibody (Biotin)See all Soluble TNF Receptor II primary antibodies ...
- DescriptionRabbit polyclonal to Soluble TNF Receptor II (Biotin)
- Tested applicationsELISA, WB more details
- Species reactivityReacts with: Human
Recombinant full length protein (Human).
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPreservative: None
- Concentration information loading...
- PurityImmunogen affinity purified
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab17552 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||ELISA: Use a concentration of 0.15 - 0.3 µg/ml.|
|WB||WB: Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 48 kDa.|
- FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
- Sequence similaritiesContains 4 TNFR-Cys repeats.
modificationsPhosphorylated; mainly on serine residues and with a very low level on threonine residues.
A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
- Cellular localizationSecreted and Cell membrane.
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References for Anti-Soluble TNF Receptor II antibody (Biotin) (ab17552)
ab17552 has not yet been referenced specifically in any publications.