Anti-Solute carrier family 22 member 5 antibody (ab125416)

Overview

  • Product name
    Anti-Solute carrier family 22 member 5 antibody
    See all Solute carrier family 22 member 5 primary antibodies
  • Description
    Rabbit polyclonal to Solute carrier family 22 member 5
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 305-354 (GIVVPSTIFD PSELQDLSSK KQQSHNILDL LRTWNIRMVT IMSIMLWMTI) of Human Solute carrier family 22 member 5 (NP_003051).

  • Positive control
    • OVCAR 3 lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125416 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 63 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Function
    Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
  • Tissue specificity
    Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.
  • Involvement in disease
    Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP) [MIM:212140]. CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy.
  • Sequence similarities
    Belongs to the major facilitator superfamily. Organic cation transporter family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CDSP antibody
    • High-affinity sodium-dependent carnitine cotransporter antibody
    • OCTN2 antibody
    • OCTN2VT antibody
    • Organic cation/carnitine transporter 2 antibody
    • S22A5_HUMAN antibody
    • Slc22a5 antibody
    • Solute carrier family 22 (organic cation/carnitine transporter) member 5 antibody
    • Solute carrier family 22 member 5 antibody
    see all

Images

  • Anti-Solute carrier family 22 member 5 antibody (ab125416) at 1 µg/ml + OVCAR 3 lysate at 10 µg

    Predicted band size : 63 kDa


  • Predicted band size : 63 kDa

References

ab125416 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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