FunctionReceptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.
Tissue specificityFetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.