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Product Name
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Somatostatin Receptor 1 antibody
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See all Somatostatin Receptor 1 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to Somatostatin Receptor 1
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Immunogen
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Synthetic peptide: C-LKSRAYSVEDFQPENLES, corresponding to C terminal amino acids 358-375 of Rat Somatostatin Receptor 1.
BLAST 'C-LKSRAYSVEDFQPENLES' with  or 
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Reacts with
(species key)
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Hu, Ms, Rat
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Specificity
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Specific to Somatostatin Receptor I (sst1) and does not react with Somatostatin Receptor II (sstII).
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Tested applications
(see key)
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IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IP: Use at an assay dependant dilution.
WB: 1/1000 - 1/5000. Predicted molecular weight: 60 kDa.
Has not been shown to work in ICC.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane
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Research areas
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Neuroscience >> Neurology process >> Neuroendocrinology >> GH Regulation
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> More GPCR
Neuroscience >> Neurotransmitter >> Neuropeptides >> Hormones
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Relevance
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Somatostatin Receptor (SSTR) 1 is one of the five receptor subtypes termed SSTR 1 to 5. They are G-protein-coupled receptors characterized by seven transmembrane helices with an extracellular amino terminal domain and an intracellular carboxy terminus. These receptors are activated by somatostatin secreted by nerve and endocrine cells and function in the regulation of numerous physiological processes such as the secretion of insulin, glucagon and growth hormone. The SSTRs also play a role in cell growth induced by neuronal excitation in both the central and peripheral nervous system.
Somatostatin acts to regulate numerous physiological processes by binding to and activating specific receptors in target tissues. Activation of these receptors by somatostatin, which is secreted by nerve and endocrine cells, regulates the secretion of insulin, glucagon and growth hormone, neuronal excitability in both the brain and the peripheral nervous system, and cell growth. Somatostatin receptors have been implicated in numerous diseases ranging from Alzheimer's to cancers of the gastrointestinal tract, breast, prostate, and pituitary.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: 0.05% Sodium Azide
Constituents: Serum Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Somatostatin Receptor 1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Somatostatin Receptor 1
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