Overview

  • Product nameAnti-Somatostatin Receptor 2 antibody
    See all Somatostatin Receptor 2 primary antibodies
  • Description
    Rabbit polyclonal to Somatostatin Receptor 2
  • SpecificityThis antibody is specific for Somatostatin R2
  • Tested applicationsSuitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:

    C-ERSDSKQDKSRLNETTETQRT

    conjugated to KLH, corresponding to C terminal amino acids 339-359 of Rat Somatostatin Receptor 2.

Properties

Applications

Our Abpromise guarantee covers the use of ab9550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. (75-85 kDa band expected).Multiple smaller MW bands may also be seen.
ICC/IF 1/100 - 1/250.
IHC-P Use at an assay dependent dilution.

Target

  • FunctionReceptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.
  • Tissue specificityCerebrum and kidney. In lesser amounts in jejunum, colon and liver.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Somatostatin receptor type 2 antibody
    • SRIF-1 antibody
    • SRIF1 antibody
    • SS-2-R antibody
    • SS2-R antibody
    • SS2R antibody
    • SSR2_HUMAN antibody
    • SST2 antibody
    • SSTR2 antibody
    see all

References for Anti-Somatostatin Receptor 2 antibody (ab9550)

This product has been referenced in:
  • Ramírez C  et al. Expression of Ki-67, PTTG1, FGFR4, and SSTR 2, 3, and 5 in nonfunctioning pituitary adenomas: a high throughput TMA, immunohistochemical study. J Clin Endocrinol Metab 97:1745-51 (2012). IHC-P ; Human . Read more (PubMed: 22419713) »
  • Fasciani A  et al. Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions. J Clin Endocrinol Metab 95:5315-9 (2010). IHC-P ; Human . Read more (PubMed: 20739383) »

See all 2 Publications for this product

Product Wall

I am very pleased to hear you would like to accept our offer and test ab9550 in WB on Chicken. This code will give you 1 free PRIMARY ANTIBODY before the expiration date. To redeem this offer, please submit an Abreview for Chicken and include this code...

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Thank you for contacting us.

A quick search of SSTR2 does show low expression in tissues of the CNS with the exception of granular and molecular layer cells in the cerebellum. However, if this protein is present in spinal tissue and you ar...

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Ab9550 was tested in immunofluorescence, but has not yet been tested with paraffin-embedded or frozen sections in IHC.

Thank you for your enquiry. To our knowledge, this antibody has yet to be tested in IHC; I cannot recommned a type of fixation at this time. All tested applications are specified on Abcam product datasheets. If you decide to go ahead and purchase this ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"